CdcA3 Polyclonal Antibody

Cell cycle events are regulated by the sequential activation and deactivation of cyclin-dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division control (Cdc) genes are required at various points in the cell cycle. CdcA3 (Cell division cycle-associated protein 3), also known as TOME1 (Trigger of mitotic entry protein 1) and GRCC8 (Gene-rich cluster protein C8), is a 268 amino acid cytoplasmic protein that is required for entry into mitosis. By participating with E3 ligase complexes, CdcA3 is involved in the ubiquination and degradation of the mitosis-inhibitory kinase Wee 1, leading to the dephosphorylation of Cdc2 in the late G2 phase. CdcA3 itself is targeted for destruction by anaphase-promoting complex (APC) in the G1 phase of the cell cycle, then allowing for Wee 1 accumulation during interphase.

 

Dosage options: 20uL / 50uL / 100uL