Human red blood cell-derived extracellular vesicles

Description

Extracellular vesicles (EVs) are naturally derived, lipid bilayer-enclosed particles released by cells. EVs have been shown to play a major role in regulating physiological and pathological diseased conditions by facilitating intercellular communication. EVs can be isolated from most cells and used for a variety of therapeutic or diagnostic applications. They carry diverse cargo including RNAs, proteins, and lipids derived from their parental cells. JOT-HRBCEV-A1 consists of highly purified population of EVs purified from human red blood cells displaying a homogenous size distribution ranging from ~50-250 nm). These EVs were purified from pre-isolated red blood cells and undergone a rigorous purification workflow that ensures the absence of co-elutants and impurities such as lipoproteins or serum proteins. These EVs can be utilized as a nanocarrier for the delivery of therapeutic cargo or as a positive control in EV experiments and analyses. RBCEVs can be detected with high sensitivity and specificity using anti-GPA antibodies or by labelling with EV-specific dyes.

Concentration:
– For lyophilized powder: 1 to 1.5*10^11 particles per vial.
– For frozen suspension: 1 to 10*10^9 per microliter (specified on the vial).

Link: Datasheet