LEDGF Monoclonal Antibody

A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. This aberration occurs through the translocation t(9|11)(p22|p15) with NUP98, resulting in an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. Residues 340-417 of PSIP1 constitute the domain necessary and sufficient for its interaction with HIV-1 IN (IBD domain). Functionally, PSIP1 acts as a transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. It plays a significant role in regulating gene expression in lens epithelial cells and is associated with stress responses. Moreover, PSIP1 is believed to contribute to the terminal differentiation of lens epithelial cells into fiber cells and may provide protection during stress-induced apoptosis. Isoform 2 of PSIP1 functions as a more general and stronger transcriptional coactivator.

 

Dosage options: 50uL / 100uL