VASP(Phospho Ser157) Polyclonal Antibody

VASP (Vasodilator-stimulated phosphoprotein) is a member of the Ena-VASP protein family, characterized by the presence of an EHV1 N-terminal domain responsible for binding proteins with E/DFPPPPXD/E motifs, thereby directing Ena-VASP proteins to focal adhesions. Within the protein’s middle region, there is a proline-rich domain that interacts with SH3 and WW domain-containing proteins. The C-terminal EVH2 domain facilitates tetramerization and binds both G and F actin. VASP is involved in filamentous actin formation and likely plays a significant role in cell adhesion and motility. Additionally, VASP may participate in intracellular signaling pathways that regulate interactions between integrins and the extracellular matrix. The activity of VASP is regulated by cyclic nucleotide-dependent kinases PKA and PKG.

Dosage options: 20uL / 50uL / 100uL

Link: Datasheet